Lahcen Jaafar Publishes Two Papers

Lahcen JafaarLahcen Jaafar, Research Associate in  the Dynan Laboratory, recently published a first-author paper in PloS One entitled, “Long-term effects of ionizing radiation on gene expression in a zebrafish model.” Results indicated that single, low-dose developmental exposure to γ-rays affects the expression levels for hundreds of genes that are unaffected in the acute radiation response. The work further develops zebrafish as a genetically tractable model for addressing mechanisms by which radiation injury translates into long-term effects.

Lahcen Jafaar FigureLahcen also recently published a joint first-author paper in Nucleic Acids Research, entitled, “Receptor-mediated delivery of engineered nucleases for genome modification.” The work describes a method for ligand-mediated delivery of zinc finger nucleases (ZFNs) as protein therapeutics using transferrin receptor-mediated endocytosis. The approach is flexible and general, with the potential for extension to other targeting ligands and nuclease architectures.